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【Continuous Manufacturing】Automatization of Oral Pharmaceutical manufacturing / Continuous manufacturing by FREUND CORPORATION Machinery 2021.08.31

【Continuous Manufacturing】Automatization of Oral Pharmaceutical manufacturing / Continuous manufacturing by Freund Corporation

The following advantages of “continuous manufacturing” are introduced by pharmaceutical companies who already adopted it.

1. Labor cost saving, unmanned operations (cost reduction)
2. Adaptability to required production amount
3. Automation to reduce risk of human error
4. Improvement for production flexibility and efficiency
5. Scheduling manufacturing according to production capacity without inventory
6. Quality improvement and stable supply
7. Ease of maintenance brought by small footprints manufacturing facilities

(*2) “Autonomation” is a term used in Toyota Production System(TPS).
This term is distinguished from general automation and must meet following conditions.
1. No human monitoring or involvement is required during normal operation.
2. In the event of abnormality, the safety side will automatically stop or fallback.
3. Then call for human involvement with alarms, etc.
4. These series of operations are systematized so that operators can perform other tasks during normal operation.

We have evolved our autonomation by adding the following three conditions.
5. Detect signs that critical quality characteristics may deviate from control range during manufacturing and control manufacturing conditions to prevent deviations.
6. Even if non-standard product is generated, remove it from the system with high accuracy and certainty.
7. Equipped with functions to support DI (Data Integrity)

Continuous manufacturing for oral pharmaceutical products at site has been started and the number of products is gradually increasing.
This article outlines the advantages of adopting continuous manufacturing method and its system we sell.
In Japan, manufacturers have to overcome increasingly severe business environment such as pursuing lower drug manufacturing cost due to annual price revisions, accelerating labor shortage by declining birthrate and aging population, and the needs of work style reform.
It is required to realize timely manufacturing to prevent drug shortage overseas, at the same time in Japan, to improve productivity, prevent human error and protect manufacturing workers.

The introduction of continuous manufacturing system is considered to be a technology that can overcome such issues and our system is evolving day by day.
Our continuous systems are also evolving day by day.
We would appreciate it if you pay attention to the latest information.

Please feel free to contact us using the inquiry form below or our sales representative for details of the system or for consultation regarding trial with equipment.

KEYWORD: Pharmaceutical industry Health Food Industry Chemical Industry Granulation Continuous production Autonomation equipment

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