CMEC™
-
Application
CMEC® (Carboxymethylethylcellulose) is mixed ether obtained by partially carboxymethylated and ethylated of cellulose.
Listed in the Japanese Pharmaceutical Excipients,and this product is used for controlled drug-release formulations mainly as an enteric film-coating base. This product is also used as a carrier of solid dispersion for the purpose of improving the solubility of poorly-soluble drugs.
FEATURE
- High stability
Since it is composed of ether bonds, it is not easily hydrolyzed and is chemically stable. - pH-dependent disintegration
The disintegration behavior of tablets coated with CMEC™ is pH dependent, independent of the type of buffer solution.
At a low pH level, it does not easily disintegrate, and at a high pH level, quickly disintegrate. By utilizing this property to control drug elution, CMEC™ can be used as an enteric base.
Also, various elution patterns can be formed in combination with pH-independent sustained-release bases. - Application as a matrix base
This is also used for matrix formulations that contain APIs in CMEC™.
By changing the ratio between the APIs and CMEC®, the drug release speed can be controlled. - Improvement in elution of poorly-soluble drugs
By preparing solid dispersion of poorly-soluble drugs with CMEC™, the elution performance of drugs is improved. - Protective coating for sugar-coated tablets
As an approximate 100 µm thick CMEC™ film exhibits a sufficient moisture-resistant effect, this product can be used as a protective coating base when tablets containing water-sensitive APIs are sugar-coated.
- High stability
PACKING FORM
Related Documents
Related Links
- SHARE
- Share
- tweet
- Send to LINE
- Send to Mail